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In Salmonella typhimurium TA100 and TA104, strains that show a clear mutagenic response to acrolein, DNA-acrolein adducts have also been identified (section 7.6.1)

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Medullary Thyroid Carcinoma or MEN 2 , Patients with a personal or family history of medullary thyroid carcinoma, or those diagnosed with Multiple Endocrine Neoplasia syndrome type 2, should not use tirzepatide