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Cycling Considerations Most protocols recommend cycling off after 12 to 16 weeks to prevent potential receptor desensitization and maintain hormonal sensitivity

Among the derivatives, compound 44 (Figure 3) exhibited the most potent activity with IC 50 values ranging from 11.9 to 37.5 g/mL against both promastigote and amastigote forms and lowest cytotoxicity, significantly outperforming the standard drugs amphotericin B and Glucantime