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In a mouse model of ALS (SOD1 G93A), 5-MTHF levels are significantly reduced in the plasma, spinal cord, and cortex at the pre-symptomatic stage, whereas Hcy levels are markedly increased following the onset of motor symptoms in the ALS mice [192]

Rather than engineer a new single molecule, Novo Nordisk paired an existing approved GLP-1 drug (semaglutide 2.4 mg) with a novel long-acting amylin analogue (cagrilintide)

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