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The generation of ROS can adversely affect the structure and function of the GA, potentially leading to modifications in stress signaling pathways downstream ( 9.1 Chondroitin sulfate Chondroitin sulfate, a polysaccharide abundant in the extracellular matrix and on cell surfaces, possesses a sugar chain structure consisting of glucuronic acid and N-acetylgalactosamine (GalNAc) (Figure 14A) (Figure 14B) ( FIGURE 14 2022 Elsevier Ltd

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From a biomechanical perspective, one of the earliest functional consequences of such alterations is a change in activity variability

Previous studies in patients with rheumatoid arthritis had increased cell membrane rigidity compared to membranes from those receiving immunomodulatory treatment