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The function and alteration of nAChRs are involved throughout the pathological cycle of Parkinsons disease (PD), and their distribution in the human brain is closely associated with the progression of PD

For patients, I know the exhaustion of hearing the same lines over and over: We'll just watch your labs Keep your blood pressure under control We'll talk about dialysis when the time comes. I have seen the hopelessness in people's eyes as they leave appointments believing their decline is inevitable

Henrici, R

However, the phenomena that induce OS attributable to the patients aging, in addition to being variable in terms of intensity among individuals, are difficult to distinguish from those produced by the compromised antioxidant defense systems due to a neurodegenerative disease, such as ALS