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However, it should be recalled that most results obtained so far derive from preclinical studies, and in vivo investigations in humans are thus necessary to fill this gap

Inhibiting the SREBP-regulated feedback response together with statin therapy could prevent drug resistance and increase the antitumoral efficacy of statins

12 Now we recognize that ROS can be generated through mechanisms such as the mitochondrial electron transport chain, the endoplasmic reticulum, and NOX