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Instead of serving as structural building blocks, they may influence how cells communicate, migrate, or organize

In contrast to the oral delivery, the rectal route may provide, in addition to the possibility of bypassing hepatic first-pass elimination, the advantage of reduced proteolytic degradation for peptides and proteins and thus improve systemic bioavailability, especially when they are administered with absorption promoting adjuvants

This supports the notion that only TICs or TIC-like cells grow in soft gels

of note, the Wnt response appears normal in this Axin2 KO line as wt Axin1 compensates for the loss of Axin2)