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Additionally, deprivation of Cl - facilitates Ca 2+ influx by promoting the release of PGE2 [91]

Figure 3 summarizes the major inflammatory pathways activated by mitochondrial DAMPs, including TLR9, NLRP3, and cGAS-STING signaling, and their systemic consequences

Consistent with previous findings, the protein levels of TJPs (claudins, occludin, and zonular occludens-1) were downregulated, and the activities of MMP9 and MMP2 were enhanced in delayed tPA treatment, which implied that the BBB integrity had been compromised