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16 (12), e0261127 (2021)

Our preliminary interpretation is that replacement of Tyr110 indeed affects the interaction with GSH but, as compared to K105A/Y, does not drastically alter the ratio between the steady-state concentrations of the deprotonated and glutathionylated enzyme species E and F, respectively

Proteins linked to neutrophil degranulation are more abundant in patients with AH compared to AUD and controls and are associated with disease severity

The observed upregulation potentially indicates that N , N -dimethylglycine may play a role in the pathophysiology of these conditions, particularly in more severe manifestations of PE