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Under-eye dermal fillers , also known as tear trough fillers , are injectable treatments designed to restore volume and reduce the appearance of hollowness and shadowing beneath the eyes

(E and F) NCI-H446 cells overexpressing Flag-CRIP1 WT, R16K, or R16F at day W8 post-chemotherapy were cultured under low-adhesion conditions, seeded into soft agar, stained with crystal violet, photographed, and counted after 14 days (scale bar: 300 m)