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Abemaciclib plus trastuzumab with or without fulvestrant versus trastuzumab plus standard-of-care chemotherapy in women with hormone receptor-positive, HER2positive advanced breast cancer (monarcHER): a randomised, open-label, phase 2 trial

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IGFs are bound in binary (to IGFBPs) or ternary complexes (IGF-ALS-IGFBP-3 or -IGFBP-5), with little free IGF-I or IGF-II in either the circulation or the extracellular fluid