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(Fuzhou, China)

T2DOP is a common complication of T2DM and is associated with an imbalance in iron homeostasis caused by metabolic alterations in T2DM [112,113,114]

However, when the drug is taken in an overdose, the Uridine diphosphate-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs) in the human liver that participate in APAP detoxification become saturated, and a considerable proportion of this drug is activated by human CYPs (primarily CYP2E1)

By interpreting the perturbations occurring upon drug treatment at the metabolic pathways level, a more comprehensive understanding of the impact of drugs on the complexity of cells metabolic networks can be achieved