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Description

In the nucleus, protein phosphatase 2 A (PP2A)-mediated dephosphorylation at serine 298 residue affects the interaction of the nuclear localization signal of HDAC4 and MEF2, finally altering the neuronal activity

Polymorphisms arise from the occurrence of gene conversion events, deletions, duplications, multiple nucleotide insertions/deletions, and SNPs

It protects neuronal cells by mitigating oxidative stress, reducing inflammation, and enhancing mitochondrial function, thereby alleviating cerebrovascular injury and slowing the progression of VaD