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doi: 10.5732/cjc.008.10786 146 LiuYJiRLiJGuQZhaoXSunTet al

Interestingly, IPF patients expressing MUC5B risk alleles have a significantly lower bacterial burden compared with the patients who do not bear the risk allele (Molyneaux et al., 2014)

Moreover, it significantly reduced fasting blood glucose levels by approximately 50% and body weight by around 19% in the treated mice

Other examples include the recently reported ability of nuclear IGF-1R to drive chemotherapy resistance in various types of cancer, and notably, through interactions with nuclear mitotic apparatus (NuMA) protein and regulating p53binding protein 1 (53BP1) dependent DNA doublestrand break repair in colorectal cancer (40)