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doi: 10.1002/cphy.c150015 [DOI] [PMC free article] [PubMed] [Google Scholar] 228

A shot skips that route

The GSH affinity chromatography empty capsid clearance of the virus harvested from the most productive infection temperature of 34C was compared to the original infection setpoint of 37C

5-Amino-1MQ acts as a competitive inhibitor with respect to the nicotinamide substrate (submicromolar IC50), increasing the intracellular nicotinamide available for NAD+ salvage via NAMPT - which is then studied for downstream effects on NAD+-dependent sirtuins and mitochondrial function