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With oral supplementation, we are limited in how high we can dose nutrients due to risk of gastric irritation and other unpleasant side effects

5-Amino-1MQ Vials (10 mg each): 1 week (5 mg/day = 35 mg total) 4 vials 2 weeks (5 mg/day = 70 mg total) 7 vials 4 weeks (5 mg/day = 140 mg total) 14 vials Insulin Syringes (U-100, 1 mL): 1 week (once daily): 7 syringes 2 weeks (once daily): 14 syringes 4 weeks (once daily): 28 syringes Bacteriostatic Water (10 mL bottles): Use 2.0 mL per vial for reconstitution

Orally bioavailable lead candidates will be tested in a comprehensive doseranging study to confirm efficacy on obesity and co-morbid endpoints

In a further aspect of the invention, one or more cations chosen from Tables 3a and 3b is contacted with a cell expressing NNMT followed by contacting said cell expressing NNMT with one or more cations of the invention