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One case of heterogeneity is due the up regulation in endothelial cells, associated with tumours, of the PI3K/AKT pathway which has been reported in some intra tumour endothelial cells [72] , one of the consequences is the variable response to angiogenic factors like VEGF and to their blockage [73]

These conditions typically include hypertension, cancer, and diabetes

Clinical applications further demonstrate ozones versatility for joint conditions through various administration methods