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Scavenging reactive oxygen species selectively inhibits M2 macrophage polarization and their pro-tumorigenic function in part, via Stat3 suppression

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However, a contradictory study shows that CCR2 [the receptor for CCL2 known to be expressed by microglia (van der Meer et al., 2000)] was detected in human fetal astrocytes and mediated their chemotaxis ( Changes to chemokine levels may have relevance to neurodegenerative diseases with plasma CCL2 increased in MCI and AD patients (Lee et al., 2018) and correlated to memory decline (Xia et al., 1998)

48,50 NI is a cascade of reactions and immune events, resulting in NDG, and some evidence is developing that OS and NI both contribute to the pathophysiology, onset and progression of NDG