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Despite the complexity of TMAOs role in atherosclerosis, studies have indicated that managing TMAO through nutrition, medication, or microbiome modification may help lessen its effects and even reverse its contribution to the advancement of the disease [73, 76]

LC is an amino acid analogue naturally occurring in the human body (13)

J Biotechnol Biomed

More specifically, curcumin I (diferuloylmethane) does not affect the miR-148a expression, while curcumin II (desmethoxycurcumin) downregulates, while curcumin III (bisdemethoxycurcumin) upregulates the miR-148a expression [48]