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This results from G3P accumulation upstream and shunting of hexose monophosphates to the oxidative phase of the PPP to generate nicotinamide adenine dinucleotide phosphate (NADPH), which in turn fuels antioxidant systems

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(2016) [165], up-regulation of Grx1 in microglia cells results in proinflammatory signalling which ultimately leads to neuronal death in co-culture systems