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Moreover, when disease (preeclampsia and preterm birth) is present in the placenta, melatonin receptor activity and melatonin levels are both decreased (34, 84)

Influx transport systems at the BBB include SLCs and receptor-mediated endocytosis that contribute to nutrient delivery [2, 27]

Future studies are required to clarify the limits of the redox window above which ROS become damaging, regulators of placental vascularization and angiogenesis, redox adaptation of the placenta to ensure positive pregnancy outcome, altered expression of antioxidant genes and underlying mechanisms through which OS affects pregnancy outcome