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Description

To facilitate comparison across tumor types, we summarized representative DTP-associated molecular markers and transcriptional signatures across major cancer contexts ( Table 2 )

To harness the protein-degradation activity of this HSP90 chaperone complex, we developed a novel targeted protein degradation technology, termed Chaperone-Mediated Protein Degradation (CHAMP), and an ERK5-CHAMP was designed to induce chemical proximity between HSP90 and ERK5 to induce ERK5 degradation