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Finally, in the co-cultured model, we treated H69 cells in the insert with AA in the presence or absence of a STAT3 activator(Colivelin)and found STAT3 activation of H69 cells suppressed the THP1 mRNA expression of M1 cytokines and induced THP1 M2 gene expression

By combining genetic manipulation tools, gene editing technologies, and multi-omics analysis, we can continuously develop more precisely targeted live bacterial strains, optimize the particle size of oral formulations using diverse packaging materials, and enhance the therapeutic efficacy of engineered live bacteria through synergistic drug combinations [229]

doi: 10.1007/s11306-020-1648-5 26 KasakinMFRogachevADPredtechenskayaEVZaigraevVJKovalVVPokrovskyAG