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Hematology, 23(9), 653657

doi: 10.1007/s00210-023-02510-9 73 WangYYuHWangSGaiCCuiXXuZet al

This decline creates several problems: Low NAD+ leads to reduced DNA repair capacity and more DNA damage Decreased NAD+ hurts mitochondrial fatty acid -oxidation and oxidative phosphorylation NAD+ depletion affects all hallmarks of aging The good news is that restoring NAD+ has shown great results in preclinical studies