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Hu X, Fujimoto J, Ying L, Reuben A, Chen R, Chow CW, Canales JR, Sun W, Hu J, Parra Cuentas ER, Behrens C, Wu CJ, Swisher SG , Zhang J, Heymach J, Hong WK, Wistuba II, Futreal PA, Su D, Zhang J

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Periodic safety monitoring is required for these and certain other DMTs, including: Interferon (complete blood count [CBC] with differential and liver function every 3-6 months) S1P modulators (ocular examination whenever a change in vision is noted, CBC with differential every 3-6 months, periodic liver enzyme testing for fingolimod and if clinically indicated for other S1P modulators) Fumarates (CBC with differential and liver function testing every 3-6 months) Teriflunomide (CBC with differential every 3-6 months, liver function every month for first 6 months then every 3-6 months) Cladribine (age-appropriate cancer screenings, CBC with differential 2 and 6 months after starting each course

Children with otitis media showed better recovery rate and lesser need for surgery in the oral NAC group as compared to controls (122, 123)