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Genes Dev (2020) 34(19-20):137391

it is triggered by biological signalling pathways that go wrong when your gut ecosystem is out of balance

Glycogen synthase kinase-3 (GSK3) and protein kinase A (PKA) have been shown to be involved in the phosphorylation of tau proteins, which are in turn important in microtubule assembly and the synaptic plasticity and function of neurons (Kolarova et al., 2012)