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*Correspondence: Michael Gnzle, [email protected] This article was submitted to Food Microbiology, a section of the journal Frontiers in Microbiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Trace micronutrients form a metal-vitamin synergistic network: Vit C directly reduces O 2 /OH/HO and regenerates GPx and Vit E, activating Nrf2 [544] while inhibiting NF-B-NLRP3 [544], which increases Occludin/Claudin-1/ZO-1 [545]