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After being absorbed, B12 is gradually released from the sucrosome vesicles within the enterocytes and then transported into the bloodstream, leading to elevated circulatory B12 levels.This mechanism ensures that Sucrosomial B12 is absorbed efficiently, even in the presence of compromised IF function or damage to the ileum

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Risk factors that should prompt consideration of B12 deficiency include advancing age (reduced stomach acid production), strict vegan or vegetarian diets, pernicious anaemia, gastrointestinal surgery (particularly gastric bypass or ileal resection), long-term use of certain medications (metformin, proton pump inhibitors, H2-receptor antagonists), nitrous oxide exposure (including recreational use), and conditions affecting the gut such as Crohn's disease or coeliac disease