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Description

In one embodiment, a=1 and b=0 and, preferably, when 2 of AA 1 to AA 6 are replaced, AA 3 is replaced by Asp and AA 4 is replaced by Glu

4a and Extended Data Fig

Risks factors include age under 24 months (especially those with organic brain disease), developmental delay, coincident congenital metabolic disorders, previous liver dysfunction, or severe epilepsy treated with polytherapy or ketogenic diets [23, 51, 52]