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Glossary AD Alzheimers Disease AKT Protein kinase B APP Amyloid precursor protein ATP Adenosine triphosphate BDNF Brain-derived neurotrophic factor CREB cAMP response element-binding protein CTX Cortex C/EBP CCAAT-enhancer-binding proteins EA Erinacine A EB Erinacine B EC Erinacine C EF Erinacine F EL Erinacine L ERK1/2 Extracellular signal-regulated kinase 1/2 ES Erinacine S EZ1 Erinacine Z1 EZ2 Erinacine Z2 GLT-1 Glutamate transporter 1 GSK-3 Glycogen synthase kinase-3 beta HE Hericium erinaceus HEM Hericium erinaceus mycelia HEME Hericium erinaceus mycelia extracts Hip Hippocampus H 2 O 2 Hydrogen peroxide HO-1 Heme oxygenase-1 ICR Institute of Cancer Research IFN- Interferon-gamma IL-6 Interleukin-6 iNOS Inducible nitric oxide synthase JNK c-Jun N-terminal kinase LIMK2 LIM domain kinase 2 LPS Lipopolysaccharide MAPK Mitogen-activated protein kinase MPP+ 1-Methyl-4-phenylpyridinium MPTP 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine NF-B Nuclear factor kappa-light-chain-enhancer of activated B cells NGF Nerve growth factor Nrf2 Nuclear factor erythroid 2-related factor 2 NT-3 Neurotrophin-3 OPC Oligodendrocytes progenitor cell PAK1 p21-activated kinase 1 PCR Polymerase chain reaction PI3K Phosphoinositide 3-kinase pCREB Phosphorylated CREB PRISMA Preferred Reporting Items for Systematic reviews and Meta-Analyses PS1 Presenilin 1 SAMP8 Senescence Accelerated Mouse-Prone 8 SCA3 Spinocerebellar ataxia type 3 SD Sprague Dawley SOD1 Superoxide dismutase 1 TBI Traumatic brain injury tBT Tert-butyl hydroperoxide tHI Transient hypoxia-ischemia TNF - Tumor necrosis factor-alpha Trk Tyrosine receptor kinase TrkA Tyrosine receptor kinase A TrkB Tyrosine receptor kinase B Trx Thioredoxin TrxR Thioredoxin reductase References 1 AggarwalN

Venous whole blood samples from patients were collected into 10 ml K2EDTA Vacutainers, centrifuged at 1000g for 10 min at +4C to collect 1,8 ml of plasma

In conclusion, our in vitro experiments showed that RT results in extensive mitochondrial lipid peroxidation, which LDHB silencing can further enhance, revealing that LDHB protects cancer cells from RT-induced mitochondria-associated ferroptosis

Control and TXNIP KO Cells were treated with indicated drugs, and harvested using trypsin