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Irregular intake can make gradual changes more difficult to observe

Gryglewski G, Baldinger-Melich P, Seiger R, Godbersen GM, Michenthaler P, Klbl M, et al

"Optimizing the Clinical Use of Vancomycin"

Another approach to increasing oxygen supply is by improving tumor perfusion and oxygenation, as hypoxia at the tumor site is often caused by tumor vascular system damage and abnormalities [75]