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auris ) utilised amino acid metabolism including arginine, cysteine, and methionine metabolism potentially improving their competitive fitness in pathogenesis

coli O157:H7, Staphylococcus aureus , Pseudomonas aeruginosa , and Salmonella typhi , as observed in a disk diffusion assay, where it produced inhibition zones ranging from 8.5 to 18.3 mm at 4000 g/disc (132)

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This metabolic normalisation would subsequently attenuate lactate-dependent histone lactylation and its transcriptional activation of pro-fibrotic genes such as TGF-1 and -SMA, ultimately diminishing renal interstitial fibrosis signalling pathways [34, 35]