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10.1016/j.ejmech.2025.117313 67 KerrK

A phase I, doubleblind, placebo-controlled study of the tolerance and pharmacokinetic behaviour of RP 59500

In addition, cancer cells display increased expression of phosphoribosyl amidotransferase (PPAT), the enzyme that transfers amide nitrogen from glutamine to 5phosphoribosyl pyrophosphate (PRPP), a key reaction in purine biosynthesis (Goswami et al , 2015)

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