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Rapid correction of acidosis with sodium bicarbonate in patients with diabetic ketoacidosis may cause hypokalemia, paradoxical acidosis in cerebrospinal fluid (CSF) since carbon dioxide diffuses more rapidly into CSF than does bicarbonate, and lactic acidosis since increased pH increases hemoglobin-oxygen affinity which, when combined with erythrocyte 2,3-diphosphoglycerate (2,3-DPG) deficiency in these patients, results in peripheral tissue hypoxia

Cell-based therapies for systemic lupus erythematosus

Ten to 90% of total cellular ATP in tumor cells is contributed by cytosolic glycolysis, the rest being generated through Oxphos

It is present in every cell but especially concentrated in the liver where it plays a major role in phase II detoxification, the stage in which glutathione binds to toxic molecules to prepare them to be removed from the body