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Not surprisingly, the absence of a thick mucus layer in the Calu3 LLI model led to a higher transmigration rate for MC58 and 8013 strains compared to the ALI culture (Peters et al., 2024)

However, over time, this theory has been increasingly revised as new findings emerged and newer models were proposed

Similarly, other studies have found neurotransmitter dysregulation associated with mitochondrial disease in a subset of the ASD population [190]

Despite its numerous health benefits, the oral bioavailability of CGA remains relatively low, mainly due to its binding to plant cell wall components and microbiota-dependent metabolism [1,14,15,16]