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Defining the stage-specific dynamics of this axis during progression from steatosis to steatohepatitis and fibrosis should inform multi-target strategies tailored to MAFLD progression

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The solvent was evaporated under a rotatory evaporator (RV 10 digital, IKA) to generate a thin film, which was further dried under an ultra-high vacuum (MaximaDry, Fisherbrand) for 0.5 h

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Pyruvate dehydrogenase (PDH) promotes the transportation of pyruvate into mitochondria, where it is converted to acetyl-CoA [111,112,113,114]

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Blood 84(10):161a, 1994

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