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78 MittlerR

It was also clear that expression of the immune-related genes pirk and PGRP-LB were decreased by MetR, suggesting attenuation of the inflammatory state in the aged gut (Fig

S5, S6A, S6B)

This is a scenario which overstresses the remaining beta cells, which are still capable of providing insulin in the diabetic metabolic state and thus gives rise also to more misfolded proinsulin (Lenzen 2017)