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Ficlatuzumab is currently being tested in combination with cetuximab in a Phase Ib clinical trial of recurrent and metastatic HNSCC (NCT02277197)

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M.BobbalaD.DuboisC.RamanathanS.SaucierC.et al (2017)

Most of these involve the stifle (knee) joint, where the cranial cruciate ligament, menisci, and articular cartilage work together and where the majority of canine orthopedic injuries occur: Cranial Cruciate Ligament Disease: The canine equivalent of human ACL tears, extremely common in medium to large breeds