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Interestingly, NMN could be cleaved in the extracellular milieu by the ecto-enzyme CD73 to produce NR, which in turn, can enter the cells and eventually support intracellular NAD + formation [31,32]

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The NHS notes that taking up to 2,000 micrograms daily is unlikely to cause harm in most people, though there is generally no benefit to such excessive amounts without confirmed deficiency