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This catalyzes the transfer of electrons from NADPH to oxygen, resulting in the formation of superoxide in the extracellular component as shown in Figure 4

In terms of cost-effectiveness, traditional therapies are generally inexpensive but may incur higher long-term costs due to treatment failures, drug resistance, and management of adverse effects

doi:10.1016/j.annemergmed.2023.05.024 Robblee J, Minen MT, Friedman BW, Cortel-LeBlanc MA, Cortel-LeBlanc A, Orr SL

Mice underwent 30 min transient middle cerebral artery occlusion, followed by 24 h reperfusion, and were monitored for global neurological impairments