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The investment requirements vary based on whether the CGT is administered in vivo (viral-vector or nanoparticle-delivered gene therapies) or ex vivo (therapies that modify cells outside the body and then reinfuse them)

Weekly Schedule Example Week Below is an example of a single week in each of the three phases, so you can see how the same 10-unit dose maps onto a Monday-to-Sunday grid

L-carnitine is made naturally in the body by the liver and kidneys

Measurement of reactive oxygen species and lipid ROS Intracellular ROS were assayed with the reactive oxygen species detection kit (Beyotime, Shanghai, China) as previously described [37]: cells were incubated with 10 M DCFH-DA at 37 C for 20 min, and ROS levels were detected by fluorescence microscopy (Olympus, Japan)