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Ryutaro Makise, a senior specialist explains

During the 1990s and early 2000s, research interest increased in peptide fragments capable of interacting with cellular signalling systems and molecular regulatory pathways

We note that in the CY 2021 PFS final rule (85 FR 84539) we clarified that, to the extent our policy allows direct supervision through virtual presence using audio/video real-time communications technology, the requirement could be met by the supervising physician (or other practitioner) being immediately available to engage via audio/video technology (excluding audio-only), and would not require real-time presence or observation of the service via interactive audio and video technology throughout the performance of the service

This is even more important for those who are more vulnerable