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Nitrotyrosine was postulated to be mediated by peroxynitrite, a reactive nitrogen species formed by the very rapid reaction of superoxide and nitric oxide (NO)

doi: 10.1038/s41571-019-0181-9 170 HanYLChenLQinRWangGQLinXHDaiGH

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First, genetic alterations in mtDNA, including mtDNA point mutations, diabetes-related mtDNA polymorphisms, ethnicity-specific mtDNA haplogroups, and low mtDNA copy number, have been reported to be associated with defective insulin secretion, insulin resistance, or both [4-8]