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doi: 10.3389/fevo.2018.00058 77 TodorovSDAlvesMVBuenoGCAAlvesVFIvanovaIV

10.1136/bmj.l6217 222 JohnstoneN.MilesiC.BurnO.Van Den BogertB.NautaA.HartK.et al

(2020) 7:e46978

Recent clinical metabolomics studies have provided direct evidence for this: compared with healthy controls, the levels of multiple metabolites in the Tryptophan-KP in the serum of newly diagnosed RA patients were significantly downregulated, and the levels of these metabolites were negatively correlated with disease activity indices(DAS28) and autoantibodies(anti-CCP) (Wu et al., 2025)