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Green-Med and Med diets were calorie-restricted and included daily consumption of 28 g walnuts

Resveratrol has a similar action to quercetin, but a different chemical structure, resveratrol activates antioxidant enzymes and decreases the secretion of superoxide anion, hydroxyl radical, and inflammatory cytokines by modulating the NRF2/kelch-like ECH-associated protein 1 signaling pathway and AMPK expression

Future work will use longitudinal profiling and single-cell sequencing to assess cell-type-specific GSH roles 5 Conclusion In conclusion, by leveraging multi-omics integration, the present study identified GSH metabolism as a pivotal node in SAE, while providing a comprehensive molecular framework for SAE pathogenesis, and linking microglia-driven neuroinflammation to hippocampal oxidative damage

Membranes were incubated with the appropriate primary antibody overnight on a rocker at 4 C