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Activation of this receptor triggers intracellular signaling cascades, most notably: Due to its reduced binding to IGF-binding proteins, IGF-1 LR3 remains available in its free, biologically active form for longer durations, amplifying its anabolic and anti-apoptotic effects

Rev endocrine Metab Disord (2008) 9(4):24554

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Methods Adult subjects (40 years old) included in the Korea National Health and Nutrition Examination Survey (KNHANES) from 2008 to 2017 were merged with those from the NHIS health check-up database, producing a cross-sectional dataset