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At the same time, it was agreed that symptoms affecting the central nervous system (mental function and neurological function), followed by those affecting the peripheral nervous system, are the most difficult symptoms to link to B12 deficiency (Figure 1), suggesting the need for more specific awareness in a primary medical care setting and an improvement in examination options

Proposed explanations for this difference include variations in residual -cell function, glucagon regulation, and baseline body composition

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Patients rarely wait for randomized trials before acting.