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Description

GPX4 can increase peroxidase activity, reduce the toxicity of lipid peroxides, and maintain the cell membrane lipid bilayer stability, finally inhibit ferroptosis (Koppula et al., 2018).When xc system function is damaged or intracellular cysteine is inadequate, GSH synthesis decreases, causing ferroptosis

N Engl J Med 368:19631970

10.1007/s40265-021-01621-y 140

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