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For these agents, specific reversal strategies include idarucizumab (for dabigatran) or andexanet alfa (for factor Xa inhibitors) where available

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If CMS determines that FDA has approved such a therapeutically equivalent drug under a section 505(j) ANDA, CMS will then: use the FDA's NDC Directory, including historical information from NDC Directory files such as discontinued, delisted, and expired listings provided by the FDA or published on the FDA website to determine the marketing status of such therapeutically equivalent drug and whether, during the applicable period, the therapeutically equivalent drug was marketed

The American Diabetes Association (ADA) recommends several storage-related steps to ensure insulin doesnt go bad, aside from keeping tabs on the expiration dates: Keep insulin away from extreme cold and hot places