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In comparison, in the high-overdose patient (D), the maximum number of necrosed cells was 1,754 out of 5,114 (34.29%) without zonation and increased to 1,806 when 50% zonation was applied (see Figure 4)

At 24 hours after pMCAO, the effect on the immune response was significantly increased, with over 50% of the genes with altered expression involved in the immune response